Improved Synthesis of (±)-Trichodiene – A Volatile Marker for Trichothecene Mycotoxins
نویسندگان
چکیده
منابع مشابه
Trichothecene mycotoxins from Fusarium culmorum cultures.
Chemical analysis of the culture filtrates of Fusarium culmorum CMI 14764 has demonstrated the presence of seven trichothecene mycotoxins. Major metabolites are 3-acetyldeoxynivalenol and 7 alpha, 8 alpha-dihydroxycalonectrin, with 3,15-diacetyldeoxynivalenol, deoxynivalenol, calonectrin, isotrichodermin and 12,13-epoxytrichothec-9-ene (EPT) as minor products. The occurrence of the rarely encou...
متن کاملFusarium Tri4 encodes a multifunctional oxygenase required for trichothecene biosynthesis.
Fusarium graminearum and Fusarium sporotrichioides produce the trichothecene mycotoxins 15-acetyldeoxynivalenol and T-2 toxin, respectively. In both species, disruption of the P450 monooxygenase-encoding gene, Tri4, blocks production of the mycotoxins and leads to the accumulation of the trichothecene precursor trichodiene. To further characterize its function, the F. graminearum Tri4 (FgTri4) ...
متن کاملInhibitionby Trichothecene Mycotoxins of Replication of Herpes Simplex Virus Type
The efiects of the trichothecene mycotoxins diacetoxyscirpenol, neosoluniol and T-2 toxin on the rep}ication of herpes simplex virus type 2 (HSV-2) in HEp-2 cells werc examined. The 50% inhibitory concentrations for HSV-2 replication were 2,3 ng,iml for diacetoxyscirpenol, 52,Ong/ml for neosolaniol, and 1.6ngl'ml for T-2 toxin, The addition of these toxins to the cells within 4hr atter HSV-2 in...
متن کاملFate of trichothecene mycotoxins during the processing: milling and baking.
Toxic secondary metabolites produced by fungi representing Fusarium genus are common contaminants in cereals worldwide. To estimate the dietary intake of these trichothecene mycotoxins, information on their fate during cereal processing is needed. Up-to-date techniques such as high-performance liquid chromatography (HPLC) coupled with tandem mass spectrometry (LC-MS/MS) was used for the analysi...
متن کاملDetection of polar and macrocyclic trichothecene mycotoxins from indoor environments.
A method is described for the qualitative and semi-quantitative simultaneous determination of both non-macrocyclic and macrocyclic trichothecene biotoxins from samples derived from indoor environments. The method includes extraction, sample pre-treatment and reversed-phase HPLC separation followed by tandem mass spectrometric identification and quantification using electrospray ionization on a ...
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2014
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x1400900602